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The influence of genetic syndromes on the algorithm of cleft lip and palate repair – A retrospective study

1 Department of Paediatrics, University of Pécs, Pécs, Hungary
2 Department of Otorhinolaryngology, Ferenc Flór County Hospital, Kistarcsa, Hungary
3 Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs, Pécs, Hungary
4 Department of Oral and Maxillofacial Surgery, Medical Research Centre, University of Oulu, Oulu University Hospital, Oulu, Finland
5 Department of Medical Genetics, University of Pécs, Pécs, Hungary
6 Department of Paediatrics; Paediatric Surgery, Department of Paediatrics, University of Pécs, Pécs, Hungary

Correspondence Address:
Kinga Amália Sándor-Bajusz,
School of Clinical Neurosciences, University of Pécs, Pécs
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ams.ams_77_21

Introduction: This study aimed to determine if the treatment algorithm used for nonsyndromic cleft patients required alteration to manage syndromic cleft lip and/or palate patients. Methods: The records of patients managed by the Pécs Cleft Team between January 1999 and December 2015 were analyzed retrospectively. The sources of the data included clinical and genetic records. Results: A total of 607 patients were managed by the cleft team during the study. Sixteen patients (2.6%) were noted to be afflicted with a particular identifiable syndrome. Seven different genetic syndromes and one sequence were present in the study. The Pierre Robin sequence occurred most often, comprising 50% of the cohort. The treatment algorithm used in managing nonsyndromic clefts required modification in 13 of the 16 syndromic patients. Discussion: The presence of a genetic syndrome may notably affect the treatment algorithm in children born with cleft lip and/or palate. The surgical treatment of certain associated anomalies has by necessity, priority over the timing of the reconstruction of the cleft lip and/or cleft palate in syndromic patients.

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    -  Sándor-Bajusz KA
    -  Maros TB
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    -  Sándor GK
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