Home  -  About us  -  Editorial board  -  Search  -  Ahead of print  -  Current issue  -  Archives  -  Instructions  -  Subscribe  -  Contacts  -  Advertise - Login 
 
 
     
 
ORIGINAL ARTICLE
Ahead of Print

The influence of genetic syndromes on the algorithm of cleft lip and palate repair – A retrospective study


1 Department of Paediatrics, University of Pécs, Pécs, Hungary
2 Department of Otorhinolaryngology, Ferenc Flór County Hospital, Kistarcsa, Hungary
3 Department of Dentistry, Oral and Maxillofacial Surgery, University of Pécs, Pécs, Hungary
4 Department of Oral and Maxillofacial Surgery, Medical Research Centre, University of Oulu, Oulu University Hospital, Oulu, Finland
5 Department of Medical Genetics, University of Pécs, Pécs, Hungary
6 Department of Paediatrics; Paediatric Surgery, Department of Paediatrics, University of Pécs, Pécs, Hungary

Correspondence Address:
Kinga Amália Sándor-Bajusz,
School of Clinical Neurosciences, University of Pécs, Pécs
Hungary
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ams.ams_77_21

Introduction: This study aimed to determine if the treatment algorithm used for nonsyndromic cleft patients required alteration to manage syndromic cleft lip and/or palate patients. Methods: The records of patients managed by the Pécs Cleft Team between January 1999 and December 2015 were analyzed retrospectively. The sources of the data included clinical and genetic records. Results: A total of 607 patients were managed by the cleft team during the study. Sixteen patients (2.6%) were noted to be afflicted with a particular identifiable syndrome. Seven different genetic syndromes and one sequence were present in the study. The Pierre Robin sequence occurred most often, comprising 50% of the cohort. The treatment algorithm used in managing nonsyndromic clefts required modification in 13 of the 16 syndromic patients. Discussion: The presence of a genetic syndrome may notably affect the treatment algorithm in children born with cleft lip and/or palate. The surgical treatment of certain associated anomalies has by necessity, priority over the timing of the reconstruction of the cleft lip and/or cleft palate in syndromic patients.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Sándor-Bajusz KA
    -  Maros TB
    -  Olasz L
    -  Sándor GK
    -  Hadzsiev K
    -  Vástyán AM
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed309    
    PDF Downloaded18    

Recommend this journal